Preservation of the Left Colic Artery With Apical Lymph Node Dissection in Laparoscopic Rectal Cancer Surgery

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The purpose of this study is to explore the different impacts of high and low ligation in laparoscopic rectal interior resection on postoperative anastomotic leakage and proximal bowel necrosis and stenosis, as well as the quality of life and long-term survival. In the anterior resection of rectum, the section level of inferior mesenteric artery (IMA) is still a controversial subject between the advocates of high and low ligation. The low ligation is defined as the IMA is ligated below the origin of the left colic artery while the high ligation refers to the IMA is ligated at its origin from the aorta. Nowadays the spread of laparoscopy has encouraged more frequent execution of the high ligation, which appears easier to achieve than the low ligation and also with the advantage of lower anastomosis traction but with the disadvantage of worse vascularization of the stumps as well.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
View:

• 18 Years to 75 Years (Adult, Senior).

• Colonoscopy and pathology shows rectal or sigmoid adenocarcinoma.

• Tumor located at 4-15 cm from the dentate line.

• The clinical staging of tumor by MRI within T1-4a when tumor Above the peritoneum and T3N0-2 when tumor below the peritoneum.

• Receive or not receive neoadjuvant chemotherapy based on 5-fluorouracil before surgery and radical resection is available after neoadjuvant chemotherapy.

• Anus-saving operation is available.

• ASA class: I-III.

• Well tolerate to general anesthesia.

• ECOG score: 0-1.

• Patients - can understand and are willing to take part in the clinical trial.

Locations
Other Locations
China
Xiangya Hospital of Central South University
RECRUITING
Changsha
Contact Information
Primary
Ting Zou, MD
zouting218@163.com
0086-15874865802
Time Frame
Start Date: 2018-01-01
Estimated Completion Date: 2025-12-01
Participants
Target number of participants: 466
Treatments
Experimental: Low ligation
Left colic artery (LCA) is identified, tie the sigmoid artery and superior rectal artery,Apical lymph node dissection with the left colic artery preservation is performed.
Active_comparator: High ligation
The IMA is ligated and divided at 2 cm from its origin. Apical lymph nodes dissection is performed.
Related Therapeutic Areas
Sponsors
Leads: WEIDONG LIU,MD

This content was sourced from clinicaltrials.gov